The papal seal “In Supremae dignitatis”, issued by Pope Clement VI on 3 September 1343, granted the Studium in Pisa the title of Studium Generale with various exclusive privileges, making it universally recognised. In medieval times, the Studium Generale was a higher institute of education founded or confirmed by a universal authority, namely the papacy or the empire. Pisa was among the first European cities to vaunt a papal attestation, followed by Prague in 1347 and Heidelberg in 1386.